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Acute zinc intoxication: Synthesis and clinical evaluation of 2-(2-(2-aminophenyl) disulfanyl) benzenamine for removal of zinc ions in rats

[ Sheyda Ahmadi ] - Department of Chemistry, Shahid Bahonar University of Kerman, kerman-Iran
[ Sheiva ahmadi ] - School of Chemistry, University College of Science, University of shahrood, shahrood-Iran
[ S. Jamilaldin Fatemi ] - Department of Chemistry, Shahid Bahonar University of Kerman, kerman-Iran
[ Alireza Badiei ] - School of Chemistry, University College of Science, University of Tehran, Tehran-Iran

خلاصه مقاله:

An experiment was performed using male rats to investigate the effect and ability of 2-(2-(2-aminophenyl)
disulfanyl) benzenamine (L1) to remove zinc ions from blood and body organs following the administration of
zinc chloride. Two groups of rats were given zinc orally at a daily dose of 40 and 60 mg Zn+2 /kg body weight for
60 days. After this period, all the rats that were administered to zinc were severely anemic and showed toxicity
symptoms through an increase in zinc and a decrease in iron level in blood and certain organs. The ability of 2-
(2-(2-aminophenyl) disulfanyl) benzenamine (L1) to remove zinc has been investigated by injecting of this
chelator to the rats for one week. The results showed that the zinc level existent in the blood and organs was
significantly reduced and, at the same time, the iron concentration returned to the normal level. By this
investigation we conclude that treatment with L1 at the given dose rate is safe to be used for chelation in zinc
excessively loaded rats and can remove this ion from the body.

Zinc toxicity, chelation therapy, rat